Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Short transient receptor potential channel 3 (Homo sapiens (Human)) | BDBM542462 (5-fluoro-1-[4-(4-fluorophenyl)-2-pyrimidin-4-yloxy...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.68 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ... | Citation and Details BindingDB Entry DOI: 10.7270/Q27D2ZBR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 3 (Homo sapiens (Human)) | BDBM542444 (5-fluoro-1-[4-(4-fluorophenyl)-2-(tetrazol-2-yl) c...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.03 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ... | Citation and Details BindingDB Entry DOI: 10.7270/Q27D2ZBR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 3 (Homo sapiens (Human)) | BDBM542143 (1-[2-(3-amino-1-piperidyl)-4-(4-fluorophenyl)cyclo...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4.28 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ... | Citation and Details BindingDB Entry DOI: 10.7270/Q27D2ZBR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 3 (Homo sapiens (Human)) | BDBM542121 (1-[2-(3-amino-1-piperidyl)-4-(4-fluorophenyl)cyclo...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.39 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ... | Citation and Details BindingDB Entry DOI: 10.7270/Q27D2ZBR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 3 (Homo sapiens (Human)) | BDBM542199 (1-[2-(3-amino-5-fluoro-1-piperidyl)-4-(4-fluorophe...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 6.22 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ... | Citation and Details BindingDB Entry DOI: 10.7270/Q27D2ZBR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 3 (Homo sapiens (Human)) | BDBM542439 (5-fluoro-1-[4-(4-fluorophenyl)-2-pyrazol-1-yl-cycl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 6.64 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ... | Citation and Details BindingDB Entry DOI: 10.7270/Q27D2ZBR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 3 (Homo sapiens (Human)) | BDBM542457 (6-[2-(3-amino-5-fluoro-1-piperidyl)-4-(4-fluorophe...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 7.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ... | Citation and Details BindingDB Entry DOI: 10.7270/Q27D2ZBR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 3 (Homo sapiens (Human)) | BDBM542445 (1-[4-(4-fluorophenyl)-2-(tetrazol-2-yl)cyclopentyl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 7.55 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ... | Citation and Details BindingDB Entry DOI: 10.7270/Q27D2ZBR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 3 (Homo sapiens (Human)) | BDBM542437 (1-[4-(4-fluorophenyl)-2-pyrazol-1-yl-cyclopentyl] ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 7.97 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ... | Citation and Details BindingDB Entry DOI: 10.7270/Q27D2ZBR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 3 (Homo sapiens (Human)) | BDBM542111 (1-[2-(3-amino-1-piperidyl)-4-(4-fluorophenyl)cyclo...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 8.31 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ... | Citation and Details BindingDB Entry DOI: 10.7270/Q27D2ZBR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 3 (Homo sapiens (Human)) | BDBM542456 (1-[2-(4-chloropyridazin-3-yl)oxy-4-(4-fluorophenyl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 11.3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ... | Citation and Details BindingDB Entry DOI: 10.7270/Q27D2ZBR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 3 (Homo sapiens (Human)) | BDBM542446 (1-[2-(3-amino-1-piperidyl)-4-(4-fluorophenyl)cyclo...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 14.3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ... | Citation and Details BindingDB Entry DOI: 10.7270/Q27D2ZBR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 3 (Homo sapiens (Human)) | BDBM542443 (5-fluoro-1-[4-(4-fluorophenyl)-2-(1,2,4-triazol-1-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ... | Citation and Details BindingDB Entry DOI: 10.7270/Q27D2ZBR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 3 (Homo sapiens (Human)) | BDBM542201 (1-[2-(3-amino-4,4-difluoro-1-piperidyl)-4-(4-fluor...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 17.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ... | Citation and Details BindingDB Entry DOI: 10.7270/Q27D2ZBR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 3 (Homo sapiens (Human)) | BDBM542002 (1-[4-(4-fluorophenyl)-2-(triazol-2-yl)cyclopentyl]...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 17.7 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ... | Citation and Details BindingDB Entry DOI: 10.7270/Q27D2ZBR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 3 (Homo sapiens (Human)) | BDBM542448 (4-[2-(3-amino-1-piperidyl)-4-(4-fluoro-3-methoxy-p...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 22.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ... | Citation and Details BindingDB Entry DOI: 10.7270/Q27D2ZBR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 3 (Homo sapiens (Human)) | BDBM542463 (2-[2-(3-amino-1-piperidyl)-4-(4-fluorophenyl) cycl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ... | Citation and Details BindingDB Entry DOI: 10.7270/Q27D2ZBR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 3 (Homo sapiens (Human)) | BDBM542464 (5-[2-(3-amino-1-piperidyl)-4-(4-fluorophenyl) cycl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 25.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ... | Citation and Details BindingDB Entry DOI: 10.7270/Q27D2ZBR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 3 (Homo sapiens (Human)) | BDBM542459 (6-[2-(3-amino-1-piperidyl)-4-(4-fluorophenyl) cycl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 25.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ... | Citation and Details BindingDB Entry DOI: 10.7270/Q27D2ZBR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 3 (Homo sapiens (Human)) | BDBM50439218 (CHEMBL2418809) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay | Bioorg Med Chem Lett 23: 4979-84 (2013) Article DOI: 10.1016/j.bmcl.2013.06.047 BindingDB Entry DOI: 10.7270/Q2319X9H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 3 (Homo sapiens (Human)) | BDBM542461 (1-[4-(4-fluorophenyl)-2-pyridazin-3-yloxy-cyclopen...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 32.2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ... | Citation and Details BindingDB Entry DOI: 10.7270/Q27D2ZBR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 3 (Homo sapiens (Human)) | BDBM542453 (2-[2-(3-amino-1-piperidyl)-4-phenyl-cyclopentoxy] ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 38.8 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ... | Citation and Details BindingDB Entry DOI: 10.7270/Q27D2ZBR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 3 (Homo sapiens (Human)) | BDBM542465 (5-[2-(3-amino-1-piperidyl)-4-(4-fluorophenyl) cycl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 39.2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ... | Citation and Details BindingDB Entry DOI: 10.7270/Q27D2ZBR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 3 (Homo sapiens (Human)) | BDBM542451 (4-[2-(5-amino-3,3-difluoro-1-piperidyl)-4-(4-fluor...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 42.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ... | Citation and Details BindingDB Entry DOI: 10.7270/Q27D2ZBR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 3 (Homo sapiens (Human)) | BDBM542450 (4-[2-(3-amino-4,4-difluoro-1-piperidyl)-4-(4-fluor...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 46.1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ... | Citation and Details BindingDB Entry DOI: 10.7270/Q27D2ZBR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 3 (Homo sapiens (Human)) | BDBM542119 (1-[2-(3-amino-1-piperidyl)-4-(4-fluorophenyl)cyclo...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 46.4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ... | Citation and Details BindingDB Entry DOI: 10.7270/Q27D2ZBR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 3 (Homo sapiens (Human)) | BDBM542460 (6-[2-(3-amino-1-piperidyl)-4-(4-fluorophenyl) cycl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 50.7 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ... | Citation and Details BindingDB Entry DOI: 10.7270/Q27D2ZBR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 3 (Homo sapiens (Human)) | BDBM542447 (4-[2-(3-amino-1-piperidyl)-4-(4-fluoro-3-hydroxy-p...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 58.8 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ... | Citation and Details BindingDB Entry DOI: 10.7270/Q27D2ZBR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 3 (Homo sapiens (Human)) | BDBM542452 (4-[2-(3-amino-1-piperidyl)-4-(4-fluorophenyl) cycl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 64.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ... | Citation and Details BindingDB Entry DOI: 10.7270/Q27D2ZBR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 3 (Homo sapiens (Human)) | BDBM542449 (4-[2-(3-amino-1-piperidyl)-4-(3-fluorophenyl) cycl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 69.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ... | Citation and Details BindingDB Entry DOI: 10.7270/Q27D2ZBR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 3 (Homo sapiens (Human)) | BDBM542454 (4-[2-(3-amino-1-piperidyl)-4-phenyl-cyclopentoxy]-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 72.3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ... | Citation and Details BindingDB Entry DOI: 10.7270/Q27D2ZBR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 3 (Homo sapiens (Human)) | BDBM50439220 (CHEMBL2418807) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay | Bioorg Med Chem Lett 23: 4979-84 (2013) Article DOI: 10.1016/j.bmcl.2013.06.047 BindingDB Entry DOI: 10.7270/Q2319X9H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 3 (Homo sapiens (Human)) | BDBM50439217 (CHEMBL2418811) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay | Bioorg Med Chem Lett 23: 4979-84 (2013) Article DOI: 10.1016/j.bmcl.2013.06.047 BindingDB Entry DOI: 10.7270/Q2319X9H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 3 (Homo sapiens (Human)) | BDBM542455 (6-[2-(3-amino-5-fluoro-1-piperidyl)-4-(4-fluorophe...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 118 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ... | Citation and Details BindingDB Entry DOI: 10.7270/Q27D2ZBR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 3 (Homo sapiens (Human)) | BDBM50439219 (CHEMBL2418808) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay | Bioorg Med Chem Lett 23: 4979-84 (2013) Article DOI: 10.1016/j.bmcl.2013.06.047 BindingDB Entry DOI: 10.7270/Q2319X9H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 3 (Homo sapiens (Human)) | BDBM542458 (US11274091, Example 25 | l-[4-(4-fluorophenyl)-2-(...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 209 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For TRPC6 current recording, the intracellular solution contained (in mM): 120 CsOH, 120 Aspartate, 20 CsCl, 2 MgCl2, 0.4 CaCl2, 10 HEPES, 2 Na2ATP, ... | Citation and Details BindingDB Entry DOI: 10.7270/Q27D2ZBR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 3 (Homo sapiens (Human)) | BDBM50439221 (CHEMBL2418806) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay | Bioorg Med Chem Lett 23: 4979-84 (2013) Article DOI: 10.1016/j.bmcl.2013.06.047 BindingDB Entry DOI: 10.7270/Q2319X9H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 3 (Homo sapiens (Human)) | BDBM50439216 (CHEMBL2418812) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay | Bioorg Med Chem Lett 23: 4979-84 (2013) Article DOI: 10.1016/j.bmcl.2013.06.047 BindingDB Entry DOI: 10.7270/Q2319X9H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 3 (Homo sapiens (Human)) | BDBM50273009 (CHEMBL4129809) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 282 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nebraska Medical Center Curated by ChEMBL | Assay Description Inhibition of human TRPC3 expressed in CHO cells assessed as reduction in OAG-induced calcium influx after 10 mins by fluo-4/AM dye based FLIPR assay | J Med Chem 62: 7589-7602 (2019) Article DOI: 10.1021/acs.jmedchem.8b01954 BindingDB Entry DOI: 10.7270/Q2XS5ZR8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 3 (Homo sapiens (Human)) | BDBM50439213 (CHEMBL2418815) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 316 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay | Bioorg Med Chem Lett 23: 4979-84 (2013) Article DOI: 10.1016/j.bmcl.2013.06.047 BindingDB Entry DOI: 10.7270/Q2319X9H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 3 (Homo sapiens (Human)) | BDBM50439214 (CHEMBL2418814) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 316 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay | Bioorg Med Chem Lett 23: 4979-84 (2013) Article DOI: 10.1016/j.bmcl.2013.06.047 BindingDB Entry DOI: 10.7270/Q2319X9H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 3 (Homo sapiens (Human)) | BDBM50557651 (CHEMBL4761535) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 370 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human TRPC3 expressed in HEK293 cells assessed as inhibition of GSK170-induced current in absence of extracellular calcium by whole cel... | Citation and Details Article DOI: 10.1021/acsmedchemlett.0c00571 BindingDB Entry DOI: 10.7270/Q2V69P8Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 3 (Homo sapiens (Human)) | BDBM50439227 (CHEMBL2418823) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay | Bioorg Med Chem Lett 23: 4979-84 (2013) Article DOI: 10.1016/j.bmcl.2013.06.047 BindingDB Entry DOI: 10.7270/Q2319X9H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 3 (Homo sapiens (Human)) | BDBM50557651 (CHEMBL4761535) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 430 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human TRPC3 expressed in HEK293 cells assessed as inhibition of GSK170-induced current in presence of 2 mM extracellular calcium by who... | Citation and Details Article DOI: 10.1021/acsmedchemlett.0c00571 BindingDB Entry DOI: 10.7270/Q2V69P8Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 3 (Homo sapiens (Human)) | BDBM50450629 (CHEMBL4177187) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 470 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human TRPC3 expressed in HEK293 cells assessed as inhibition of GSK170-induced current in presence of 2 mM extracellular calcium by who... | Citation and Details Article DOI: 10.1021/acsmedchemlett.0c00571 BindingDB Entry DOI: 10.7270/Q2V69P8Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 3 (Homo sapiens (Human)) | BDBM50439215 (CHEMBL2418813) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay | Bioorg Med Chem Lett 23: 4979-84 (2013) Article DOI: 10.1016/j.bmcl.2013.06.047 BindingDB Entry DOI: 10.7270/Q2319X9H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 3 (Homo sapiens (Human)) | BDBM50450629 (CHEMBL4177187) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 530 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human TRPC3 expressed in HEK293 cells assessed as inhibition of GSK170-induced current in absence of extracellular calcium by whole cel... | Citation and Details Article DOI: 10.1021/acsmedchemlett.0c00571 BindingDB Entry DOI: 10.7270/Q2V69P8Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 3 (Homo sapiens (Human)) | BDBM50450629 (CHEMBL4177187) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 540 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nebraska Medical Center Curated by ChEMBL | Assay Description Inhibition of YFP-tagged TRPC3 (unknown origin) expressed in HEK293 cells assessed as reduction carbhocol-induced receptor operated Calcium influx af... | J Med Chem 62: 7589-7602 (2019) Article DOI: 10.1021/acs.jmedchem.8b01954 BindingDB Entry DOI: 10.7270/Q2XS5ZR8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 3 (Homo sapiens (Human)) | BDBM50439232 (CHEMBL2418818) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 630 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of human recombinant TRPC3 expressed in HEK293-MSRII cells assessed as carbachol-stimulated Ca2+/Na+ influx after 10 mins by FLIPR assay | Bioorg Med Chem Lett 23: 4979-84 (2013) Article DOI: 10.1016/j.bmcl.2013.06.047 BindingDB Entry DOI: 10.7270/Q2319X9H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Short transient receptor potential channel 3 (Mus musculus) | BDBM50450629 (CHEMBL4177187) | PDB NCI pathway Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of mouse TRPC3 expressed in HEK293 cells assessed as inhibition of Ca2+ influx by whole cell patch-clamp method | Citation and Details Article DOI: 10.1021/acsmedchemlett.0c00571 BindingDB Entry DOI: 10.7270/Q2V69P8Q | |||||||||||
More data for this Ligand-Target Pair |
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